Treatment of Fluoroquinolone-Associated Disability -the pathobiochemical implications: A Polish Study

There are many articles and research papers on fluoroquinolone-associated disability (FQAD), also known as fluoroquinolone toxicity (FQT). And for years, the victims of fluoroquinolone antibiotics, like myself, have been raising the alarm on just how dangerous they can be.

Cipro, Avelox, and Levaquin are part of a class of antibiotics called fluoroquinolones. They are meant to treat life threatening infections, yet are too often prescribed to otherwise healthy patients. In our case, the treatment can be worse than the illness. Fluoroquinolones can cause widespread damage and disability. So much so that the U.S. Food and Drug Administration put a name to it- Fluoroquinolone-associated disability (FQAD). There is no treatment or cure.

With all of the articles and research papers out there, this is the first I’ve seen one that addresses the issue for what it is: a multi-system, debilitating chronic illness.

Of particular interest is that the authors state that in order to treat FQAD, more needs to be understood about how fluoroquinolones damage the body.

Until detailed knowledge concerning FQ toxicity would be recognized, the following directions in supporting FQAD patients are proposed according to the known and probable mechanisms of FQ toxicity: A. reduction of the oxidative stress; B. restoring reduced mitochondrial potential ∆Ψm; C. supplementation of uni- and bivalent cations that are chelated by FQs;D. supporting the mitochondrial replication in the cell – pulling the more destroyed to apoptosis and proliferation of the more healthy ones; E. removing FQs permanently accumulated in the cells (if this phenomenon takes place); F. regulating the disturbed epigenetics and enzyme activities” .

The article is long but worth the read to get a picture of what is known about fluoroquinolone toxicity, and what more needs to be done.

Click here for the full article.

2 thoughts on “Treatment of Fluoroquinolone-Associated Disability -the pathobiochemical implications: A Polish Study”

  1. FYI, when the authors were contacted they said they had gotten no response from this article so the team disbanded. We are doomed.

  2. My son had adverse reaction to Cipro and also Flagyl Oct 2016 of which I know both are neurotoxic . My son’s initial reaction was his brain and CNS, then one thing after another,his whole body went haywire. Currently my son is in low ejection fraction heart failure with other complications in the heart.
    His brain hasn’t recovered from the trauma as well

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